Now here's the good bit, because after James has had the cowpox
, I'm going to deliberately try to infect him with smallpox, yes, I know it's a known killer, but trust me, I know what I'm doing.
was known in Europe for many centuries as a disease of cattle, occurring as ulcers on the teats that caused similar ulcers on the hands of milkmaids.
Malcolm Skolnick, CytoGenix President and CEO commented, "We believe that there is an opportunity to develop a smallpox DNA vaccine that will be safer and more effective than the live cowpox
vaccine currently available.
Viruses in the family Poxviridae, genus Orthopoxvirus, consist of numerous pathogens known to infect humans, including variola virus (VARV), monkeypox virus (MPXV), cowpox
virus (CPXV), and vaccinia virus (VACV).
Jenner inserted pus taken from a cowpox
pustule into an incision on the boy's arm, testing his theory that milkmaids who suffered the mild disease of cowpox
never contracted smallpox.
Edward Jenner of England discovered that inoculation with cowpox
, a milder version of smallpox, was less risky and just as effective.
Edward Jenner's inoculation of people with the much less deadly cowpox
virus to protect against deadly smallpox because he noticed that milkmaids, who had had cowpox
, did not contract smallpox.
The PCR assay did not cross-react with herpes simplex virus types 1 and 2, Epstein-Barr virus, cytomegalovirus, HHV-6 A and B, HHV-7, HHV-8, simian virus 40, parvovirus B19, camelpox, cowpox
, modified vaccinia virus Ankara (MVA), or 3 clinical samples that were PCR-positive for transfusion-transmitted virus (data not shown).
Monkeypox is part of a family of viruses that cause human smallpox, cowpox
, and camelpox as well as monkeypox.
The new vaccine, called MVA85A by researchers, consists of weakened cowpox
virus that has been genetically engineered to make a protein normally found on the surface of M.
When Edward Jenner started it all in 1796 he injected a child with the cowpox
virus as a means of protecting him or her against smallpox.
Eighty years earlier, she had reported observing Turkish women applying cowpox
from the udders of cows to skin scratches on their children and then covering the cowpox
with a nut shell to protect them from future infections.
virus was used in inoculations in 1796 by Edward Jenner.
There's a theory that some of these could be used in combination as a sort of vaccine, a bit like how cowpox
was used as a vaccine against smallpox.
He wondered if the illness, known as cowpox
, somehow protected them.