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Invasion is characteristic of thyrotroph adenomas, silent corticotroph adenomas, and the unusual plurihormonal silent subtype 3 adenomas.
PPAR-gamma agonists are one of the drugs in this group, as its PPAR-gamma expression was shown in corticotroph adenomas.
Corticotroph adenomas (~10% of pituitary tumors) stain immunopositive for ACTH.
9) Galectin-3 (Gal-3) is highly expressed in functioning corticotroph adenomas of the pituitary gland, while silent adenomas exhibit very focal to null expression of Gal-3.
Clinicopathologic correlations of silent corticotroph adenomas of the pituitary: report of four cases and literature review.