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In rat and human corticotroph adenoma cell series, troglitazone and rosiglitazone decreased the tumor cell growth, increased the apoptosis and lowered the ACTH secretion by inhibiting POMC mRNA expression (16).
PPAR-gamma agonists are one of the drugs in this group, as its PPAR-gamma expression was shown in corticotroph adenomas.
55) If these patients come to surgery, usually no pituitary adenoma is identified, or there may be an incidental lesion that is not a corticotroph adenoma.
Background: Two recent whole-exome sequencing researches identifying somatic mutations in the ubiquitin-specific protease 8 (USP8) gene in pituitary corticotroph adenomas provide exciting advances in this field.
Corticotroph adenomas (~10% of pituitary tumors) stain immunopositive for ACTH.