The findings from randomized trials and observational studies indicate that epinephrine increases coronary perfusion
pressure and the likelihood of ROSC during CPR.
Effect of graded reductions in regional coronary perfusion
and total cardiac function.
To evaluate cardiac function in the various experimental groups, we determined the coronary perfusion
pressure and left ventricular systolic pressure.
Therefore, any reduction in aortic pressure not only increases coronary perfusion
pressure but also increases metabolic needs of coronary blood flow.
4) in Langendorff perfusion system (ADInstruments, Australia) at a constant coronary perfusion
pressure of 65 [+ or -] 1 mm Hg at 37 [degrees]C for 20-30 min (stabilization), then perfused at 20 [+ or -] 1 mm Hg for 40 min to produce a global low flow ischemia, and finally reperfused at 65 [+ or -] 1 mm Hg for 10 min.
pressure was measured by attaching the side arm of the aortic cannula to a pressure transducer (Isotec, Hugo Sachs Electronic, March-Hugstetten, Germany).
Early CPR, such as to restore coronary perfusion
pressure and myocardial blood flow, delays onset of ischaemic myocardial injury and facilitates defibrillation (12).
Therefore, coronary perfusion
occurs during diastole.
Secondarily, IABP improves cardiac output, increases coronary perfusion
pressures, increases systemic perfusion, reduces mitral regurgitation and reduces afterload, which will subsequently decrease left ventricular workload.
Buis goes on to state, "Chase Medical is deeply involved in, and committed to further innovative and unique product development projects which address the remaining challenges of beating heart surgery, including hemodynamic stability during cardiac manipulation, and optimal coronary perfusion
during the surgical procedure.
He continued, "This demonstrated that the increase in coronary perfusion
, along with the already published scientific data demonstrating the positive hemodynamic and neurohormonal effects of EECP therapy, makes a very strong argument for the use of enhanced external counterpulsation therapy in treating stable angina and compensated heart failure patients.
Sustained coronary perfusion
pres sure is critical to successful defibrillation.
Ischemia induced during stress protocols for echocardiography or myocardial perfusion imaging (MPI) indicates impaired coronary perfusion
in the face of increased oxygen demand.
The role of heart rate in myocardial ischemia from restricted coronary perfusion
This is important because the historical concern has been that some hemoglobin-based oxygen carriers have caused coronary vasoconstriction that would reduce coronary perfusion
and result in myocardial ischemia.