In an attempt to correct for this, most laboratories normalize BCR-ABL1 transcripts to control gene
transcripts to generate a ratio.
By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene
expression and, consequently, cell function.
Gene regulatory proteins control gene
expression in developmental and cellular processes of many organisms.
We believe the GeneSwitch technology will accelerate the throughput of genomics research because it has the unique ability to completely control gene
expression and assist in the identification and characterization of the function of selected genes.
The ability to control gene
expression in the central nervous system has potentially far-reaching implications for the treatment of a number of neurodegenerative diseases.
In recent years, it has become clear that being able to control gene
activity in cancer - manipulating which genes are 'on' or 'off' - can be a high-impact approach to the disease.
Some of this genetic clutter may control gene
expression in eggs and the earliest embryos, according to a report in the October Developmental Cell.
Washington, Feb 24 (ANI): Expression of a master control gene
called Ato in fruit flies, and ATOH1 in mammals, can suppress cancer, according to scientists at VIB and K.
It's easy to see that denizens in the ancient RNA world needed riboswitches, but why would eukaryotes and bacteria today continue to use RNA, rather than proteins, to control gene
Using retroviral vectors, the MDR1 gene was inserted into one-half of each patient's' stem cells; a control gene
was placed in the other half.
In the mammalian genome, sequences that encode proteins and those that control gene
expression are usually separate from each other.
Article Reviews On-Going Work to Control Gene
E[acute accent]"The recent discoveries that over 250 human genes encode microRNAs and that these microRNAs may control gene
expression for as much as one-third of the genome suggests that this part of the RNAi pathway plays a major role in human health and disease," said John Maraganore, Ph.
At Sangamo, we are combining a detailed knowledge of the machinery needed to control gene
regulation with a sophisticated understanding of the biochemical pathways that influence that machinery," said Dr.
Mardon emphasizes that there are many genes before and after eyeless in the genetic hierarchy driving eye development, making it impossible to pick eyeless or any other single gene as a master control gene