Cardiac function studies should routinely include, in addition to the qualitative studies of cardiac morphology and contractility
, an ability to quantify LV and right ventricular (RV) end-diastolic and end-systolic volumes (EDV and ESV), stroke volume (SV), ejection fraction (EF), and myocardial mass.
Alcohol should be avoided since it can decrease antral contractility
and impair gastric emptying.
Using their advanced understanding of cardiac contractility
, we hope to develop therapies that will improve the lives of heart failure patients around the world.
1-4,6-8) As in previous case reports, echocardiography did not show a structural cardiac lesion, nor did it show poor contractility
suggestive of cardiomyopathy.
Vitamin D, they note, is known to affect cardiac contractility
as well as calcium hemostasis in the myocardium.
The volume is also calcium-centric, exploring calcium-dependent aspects of programmed cell death, cardiac contractility
, and exocrine gland secretion.
In December 2006, Cytokinetics and Amgen entered into a strategic collaboration to discover, develop and commercialize novel small-molecule therapeutics that activate cardiac muscle contractility
for potential applications in the treatment of heart failure.
Researchers examined the impacts upon heart contractility
, electrophysiological function, coronary flow and oxygen extraction in isolated guinea pig hearts, and the direct vasodilatory activity of the extract on rat aortic rings.
Other assays determined that sceptrin limits motility by reducing cell contractility
The company's products target calcium cycling and contractility
deficit in heart muscle cells.
In these patients, providing positive inotropes to enhance myocardial contractility
The brain boosts catecholamine output to make the heart work harder, and the consequence is increased heart rate and increased contractility
Peak systolic velocity of mitral annular longitudinal movement measured by pulsed tissue Doppler imaging as an index of global left ventricular contractility
In this collaboration, Cytokinetics will combine its foremost position in the discovery and mechanistic biology of small molecule activators of skeletal muscle contractility
with Astellas advanced pharmaceutical discovery, development, and commercialization capabilities.
Many physiologically relevant hemodynamic parameters such as stroke volume, cardiac output, ejection fraction, myocardial contractility