After further research I determined that the contact inhibition
and cancer resistance in naked mole rats is due to high levels of a molecule called hyaluronan between the cells.
He said that the experiments showed that when HMM-HA was removed from naked mole rat cells, they became susceptible to tumors and lost their contact inhibition
These cells also formed cell mounds, indicating a loss of contact inhibition
(the natural process of cell growth stopping once a certain density of cells is reached).
The cells normally grew in the medium containing 10% FCS until reaching contact inhibition
and ceased proliferation, then committed to differentiation in 10% HS after 4 days (Fig.
The researchers also found that contact inhibition
in naked mole rats is controlled by two genes, p16 and p27, while in humans it is primarily controlled by p27.