was prepared by following the same method as used in the preparation of HmPVA--EPC, except that 1 g of PVA was put to 10 mL of distilled water, the mixture was heated up to 80[degrees]C for the dissolution, the PVA solution was cooled to a room temperature, and it was alkalized by being mixed with 5 mL of NaOH solution (20%).
in this work were assembled with sulfhydryl-modified RPE as the core protein.
Seattle Genetics intends to evaluate the highly potent, synthetic drugs as product candidates on their own as well as to utilize them in its antibody-drug conjugate
In addition to protecting against disease, conjugate
vaccines protect against asymptomatic carriage of the target organisms (4-7,9).
In contrast with other patents and publications relating to PEG conjugates
of interferon-beta, MVP's new European patent claims polymer conjugates
of interferon-beta-1b that have increased in vitro potency, measured with human cancer cells in culture, and methods of synthesis of these novel conjugates
," stated Dr.
Redwood Bioscience, an Emeryville, CA based company, is developing a rational protein-chemical design technology to optimize antibody drug conjugates
and peptide therapeutics.
In addition, Seattle Genetics has developed proprietary antibody-drug conjugate
(ADC) technology comprised of highly potent synthetic drugs and stable linkers for attaching the drugs to monoclonal antibodies.
Table 1 Characterization of Antibody-Drug Conjugates
are emerging as an important class of therapeutics.
The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates
The polymer conjugates
showed favorable pharmacokinetics compared to the free CPT in that (A) the mean half-life (t 1/2) for polymer bound camptothecin was 17-20 hrs compared to 2.
The product candidates encompass three platform technologies: genetically engineered monoclonal antibodies, antibody-drug conjugates
(ADCs) and antibody-directed enzyme prodrug therapy (ADEPT).
CD33 is a validated target for cancer therapy, and we intend to explore the therapeutic potential of both naked antibodies and antibody-drug conjugates
utilizing our second generation ADC technology.
We expect to use additional production suites in the Canton building to manufacture our next-generation small-drug conjugates
, which are now in development for the treatment of solid tumors and for long-term cancer maintenance therapy.
It is also a leading supplier of monoclonal antibodies, conjugates
, antibody blends and molecular-based detection kits for use in diagnostic laboratories.