difference between the open and the closed form of [beta] in the crystal structures concentrates in the catalytic domain.
They have developed a complementary strategy based on capturing receptor-proximal conformational
profiles using intra-molecular BRET-based sensors composed of a Renilla luciferase donor engineered into the carboxy-terminus and CCPGCC motifs which bind fluorescent hairpin arsenical dyes engineered into different positions in the AT1 angiotensin II receptor and the PGF2?
For example, to understand enzyme specificity, students need to simultaneously learn that binding of a substrate to its enzyme drives the latter to undergo a proper conformational
change necessary to align the various catalytic amino acid residues in the active site along with the appropriate reactive groups of this substrate.
Recent studies provide data on the molecular characteristics and conformational
properties of three cereal beta-glucans.
Direct p53 binding followed by conformational
changes appears to be a mechanism by which mutant p53 is depleted.
If I'm happy that a horse is bred to run, then I will step back and inspect the horse and see if there's anything to stop it being a racehorse - if it has any conformational
Using proprietary Surface Acoustic Wave technology, the system detects mass binding and protein conformational
changes on whole cells Providing enhanced assay speed, the acoustic biosensors improve upon many similar detection platforms by offering real-time analysis using viable cells, while eliminating the need for molecular labeling.
We report 2 new CH1641-like isolates; analyze the conformational
stability of CH1641-like isolates, BSE, and classical scrapie; and show that a reliable molecular differentiation of these 3 TSE sources is possible by an improved discriminatory WB method.
Introduced in 1989, the concept of conformal dimension has proven useful in areas including conformational
dynamics, geometric function theory, and geometric group theory.
In the present work, they elucidate that the chiral phosphorus atoms in the polymer coordinate to transition metals such as palladium, resulting in the conformational
change of the polymer and chiral transfer from P-stereogenic phosphine units to rigid conjugated linkers in the polymer backbone.
It is known that conformational
alterations of proteins result in increasing the numbers of exosed epitopes and this was attempted with the cyst antigens.
Kliger stated, "Our goal was to design peptides that have the capability to block conformational
changes within a target protein, thereby modulating its activity.
As with our entire series of Tools and Techniques books, we've designed this one to be an introduction to the novice, a refresher for the experienced practitioner, and a conformational
point of access for experts who know they must continually return to the basics--even in the most complex and state-of-the-art transactions.
We'll look at fluorescent signals and see how they change related to this fusion-pore opening," says Lindau, "to give us an idea if there are conformational
The maximum stimulation of rubber biosynthetic rate appears to be the result of a conformational
change that greatly increases the binding affinity of the enzyme for the monomer, an effect most pronounced in H.