A research team led by scientists from the Ernest Gallo Clinic and Research Center at the University of California, San Francisco found they could reduce compulsive drinking
in rats by inhibiting key neural pathways that run between the prefrontal cortex, which is involved with higher functions such as critical thinking and risk assessment, and the nucleus accumbens, a critical area for reward and motivation.
The Obsessive Compulsive Drinking
Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior.
In assessing craving, more reliance should be placed on experimentally validated, multi-item questionnaires, such as the Obsessive Compulsive Drinking
Additional week 14 results also demonstrated that these higher-CIWA subjects maintained statistical significance in other measures that included craving and the obsessive compulsive drinking
These factors were measured using the Obsessive Compulsive Drinking
Scale (OCDS), a 14-item, well-validated, reliable, sensitive measure of alcohol cravings, according to Dr.
1995), the Obsessive Compulsive Drinking
Scale (OCDS) (Anton et al.
At baseline, subjects with higher symptoms of alcohol withdrawal showed statistical significance and greater severity on such measures as the alcohol dependence scale, the obsessive compulsive drinking
scale, and drinks per drinking day, when compared to the same measures for subjects with lesser symptoms of alcohol withdrawal.
Validity of the Obsessive Compulsive Drinking
Scale (OCDS): Does craving predict drinking behavior?
Various tools will be used for baseline assessments, including the Alcohol Dependence Scale (ADS), the Structured Clinical Interview for DSM-IV (SCID), and the Obsessive Compulsive Drinking
Scale (OCDS), among others.