Introns are silent, too -- bits of genetic material that can be seen in most DNA, only to be snipped out of the complementary RNA
before it is translated into proten (SN:5/3/86,p.
The greater potency of LNA in binding complementary RNA
sequences also allows for the use of significantly shorter LNA oligonucleotide drugs which can be more effective than previous antisense or siRNA drugs.
The result is that when incorporated into oligonucleotides, LNA conveys dramatically enhanced binding affinity to complementary RNA
Antisense drugs bind to complementary RNA
sequences, such as miRNAs, inhibiting the function of miRNAs.
The Company also plans to establish complementary RNA
biology and informatics operations in Heidelberg, Germany near the EMBL.
Once inside the cell, this material is processed into short 21-26 nucleotide RNAs termed siRNAs that are used in a sequence-specific manner to recognize and destroy complementary RNA