Structure and function of the complement receptors
, CR1 (CD35) and CR2 (CD21).
Follicular dendritic cells may be multinucleate; they have complement receptors
and human leukocyte antigen-DR on their surface.
Neutrophils phagocytosed immune complexes via Fc and complement receptors
, phagolysosomes formed, and in the process of feeding, the cells regurgitated their lysosomal hydrolases to reproduce the lesions of the acute Arthus phenomenon.
For example, by linking viral or tumor associated antigens (components or subunits) of the target disease agent to a molecular adjuvant that binds to complement receptors
, it is possible to deliver the antigen directly to dendritic cells and other antigen-presenting cells which are instrumental in eliciting therapeutic responses.
In addition, complement fragments associated with immune complexes also activate cells such as macrophages and dendritic cells through specific complement receptors