These guidelines recommend possible antifungal treatment for patients with symptoms lasting >2 months, night sweats >3 weeks, weight loss of >10%, inability to work, serologic complement fixation
titer >1:16, bilateral infiltrates or involvement of at least one half of 1 lung, or prominent or persistent hilar adenopathy (23).
Because hyphal forms are rarely encountered in tissue, a correlation between complement fixation
titers and immunodiffusion result patterns has not been established in the literature.
of cases) California (25) Arizona (2) Texas (1) Common symptoms: recent chest pain, shortness of breath Positive Negative Coccidioidin skin test 6 14 Complement fixation
serology 29 1 Coccidioides spp culture 29 2 Surgical procedures (No.
tests against ZIKV and YFV antigens confirmed these interpretations.
On a serum specimen obtained about 10 days after onset of symptoms, a complement fixation
test was positive at 1:8, and immunodiffusion for IgM and IgG were both negative (Mayo Medical Laboratories, Rochester, MN).
EVALUATIONS/MEASUREMENTS: We defined a case by positive immunodiffusion serology, a [greater than or equal to] 4-fold titer rise in complement fixation
between acute and convalescent sera, or positive urinary Histoplasma capsulatum (HC) antigen.
5] Serologic tests, including complement fixation
assay, enzyme-linked immunosorbent assay, and immunoblotting assay, are available from the Centers for Disease Control and Prevention and may be of benefit in the clinical evaluation.