To assess the magnitude of cochlear damage, we counted hair cells from cochleae harvested from the same animals used for physiological studies.
The cochleae from rats exposed to CO + noise (Figure 5(b)) exhibited more substantial damage, extending over the basal third of the organ of Corti, than the noise-only subjects.
106) The neuroprotective effects of caroverine were confirmed in a study by Ehrenberger and Felix, who demonstrated that caroverine can depress the activity of glutamate receptors in the cochleae of guinea pigs.
205) In an in vivo gene therapy study, Staecker et al introduced the gene for BDNF into the cochleae of mice that had neomycin-induced cochlear damage via the replication-defective HSVbdnflac viral vector.
Most investigators believe that otoacoustic emissions--whether they be spontaneous, product distortion, or evoked--are present in healthy cochleae