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MS activity depends upon its cofactor cobalamin (Cbl), also known as vitamin [B.
Antibodies to intrinsic factor (AIFA), which block the binding of cobalamin to intrinsic factor, have been reported in 31-76% of patients with pernicious anemia.
In these circumstances, it is possible that the NO might diminish the enzyme cofactor abilities of cobalamins and produce a functional vitamin [B.
Metabolite assays in cobalamin and folate deficiency.
This hybrid method allows scientists to quickly detect and measure levels of specific individual cobalamins in food and supplement samples.
The newer technique for quantifying cobalamins uses one of two separation methods.
12] (cobalamin) deficiency is important because cobalamin is required for biosynthesis of DNA, RNA, and protein.
3] Cobalamin deficiency can have protean morbid effects on health.
Current state-of-the-art testing uses serum cobalamin levels as a screening test and serum or urine homocysteine and methylmalonic acid determinations as confirmatory tests.
Little is known about the relationship between cobalamin deficiency and mental impairment in elderly people, but cobalamin deficiency may be an important cause of mental disturbances.
If genetic factors were the only regulators of the HC concentration, the physician could decide that the low concentration of cobalamins reflected an inherited low HC.
Concentrations of holoTC were higher in cord blood when the mothers had higher total cobalamins.
Cobalamin concentrations were calculated with a calibration curve derived from samples with known concentrations of holoTC or cobalamins.
1 Holo-TC, (d) Cobalamins, (e) pmol/L pmol/L Patients Sex Day 0 Increase Day 0 Increase 1 F 47 4 221 -8 2 M 72 -11 164 -20 3 M 5 1 92 9 4 F 7 1 95 2 5 F 15 0 135 5 6 F 29 2 122 22 7 F 30 -9 384 -18 8 M 18 2 184 -32 9 M 17 3 135 -17 10 M 16 3 167 -13 11 M 7 -1 96 14 12 M 13 -1 113 5 13 F 22 -1 187 -12 14 F 15 2 201 1 15 F 6 0 149 15 16 M 12 2 155 -3 17 M 6 5 122 -28 (a) A genetic diagnosis was available for 12 patients, as described in Tanner et al.