The intraindividual variation of total HC (6%) and holoHC (6%) in our study was low compared with previously reported results for cobalamin
(9%) and hoIoTC (16%) (12), which most likely reflects that holoHC is a more stable marker over time than is holoTC, as judged from its half-life of more than a week compared with the half-life of TC, which is in the magnitude of hours (2).
In the case of cobalamin
specifically, the situation is more complex.
In contrast with previously published data (23), both the variance and the geometric mean of cobalamin
were observed to decrease with age until 14 years, after which mean concentrations remained constant (Table 1).
Interactions between hydroxocobalamin and nitric oxide (NO)--evidence for a redox reaction between NO and reduced cobalamin
and reversible NO binding to oxidized cobalamin
Alterations in the binding site of cobalamin
levels were significantly higher in the oral group than in the parenteral group at 2 months (643 [+ or -] 328 vs.
Pregnant and lactating women should eat foods rich in cobalamin
are take a daily supplement containing cobalamin
transport can be amplified by the use of proprietary nanoparticles or polymers that can greatly amplify uptake.
Methylmalonic acid serves as an indicator of cobalamin
status because its conversion to succinate requires adenosylcobalamin.
Key words: Cobalamin
deficiency, autonomic dysfunction, dysautonomia, autonomic neuropathy, serum cytokine levels
OBJECTIVE: To evaluate the use of oral cyanocobalamin therapy in the treatment of cobalamin
(vitamin B(12))-deficient anemia.
This process is dependent on one-carbon metabolism, a pathway in which folate and cobalamin
have essential roles in the recruitment and transfer of methyl groups.
For example, in a randomized trial, 6 months of homocysteine-lowering treatment with folic acid 2 mg daily, cobalamin
(vitamin B12) 0.
Also known as cobalamin
, vitamin B12 is necessary for the synthesis of red blood cells and maintenance of a healthy nervous system.
Research: Investigators set out to determine whether high doses of folic acid, pyridoxine (vitamin B6) and cobalamin
(vitamin B12) could reduce the risk of recurrent stroke over a two year period compared with low doses of these vitamins.