Orally Disintegrating Tablets can cause severe neutropenia, orthostatic hypotension, bradycardia, and syncope, seizures, myocarditis and cardiomyopathy and has been shown to increase mortality in elderly patients with dementia-related psychosis.
is a medication that was banned after several deaths of people taking it in the 1960s.
Common side-effects associated with clozapine
use are sedation, hypersalivation, tachycardia, constipation and orthostatic hypotension.
Among new generation drugs, clozapine
has the highest treatment effect but with serious hematologic side effects .
Previous research conducted by the team showed that chronic treatment with the antipsychotic clozapine
causes repression of mGlu2 expression in the frontal cortex of mice, a brain area key to cognition and perception.
On balance the toxic levels of Olanzapine and Clozapine
that caused Mrs Davies' death probably arose due to impairment of her liver function.
I really urge you, if a patient doesn't respond to two or three very adequate courses of monotherapy with drugs chosen from among the other nine atypical antipsychotic agents on the market - and that means 12 weeks at the highest tolerated dose - [to] go to clozapine
and save the patient a lot of grief," said Dr.
The FDA has approved clozapine
for use in treatment-resistant schizophrenia, which, depending on how one defines it, can apply to a large number of patients.
Fluoxetine augmentation of clozapine
treatment in patient with schizophrenia.
The results of the present study suggest that ginkgo can enhance the effect of clozapine
on negative symptoms in patients with treatment-resistant schizophrenia.
At present clozapine
is the only antipsychotic agent with proven efficacy in treatment resistant schizophrenia and some patients still fail to improve with its use.
Sertraline and clozapine
belong to antidepressant and antipsychotic drugs respectively, while imipramine is a tricyclic antidepressant.
The court also heard from doctor Ijaz Anwar of the University Hospital of North Tees who cared for Mr Hutchinson and found the drugs Sertraline and Clozapine
in his body.
Conventional antipsychotics, used for half a century to treat a range of major psychiatric conditions, are increasingly being replaced in clinical practice by so-called 'atypical' antipsychotics, which include clozapine
, risperidone, olanzapine, quetiapine, ziprasidone and aripiprazole.
A second set of vivid visual hallucinations emerged as we decreased clozapine