This bleeding can be severe or even life-threatening, especially in carriers with very low clotting factor
Current treatment is replacement of the missing blood clotting factor
by transfusing commercially prepared factor concentrates.
Additionally, the presence of specific inhibitors, commonly targeting factor VIII, can cause clotting factor
If his prothrombin time and partial thromboplastin time are abnormal, fresh frozen plasma may help correct a clotting factor
is a specialty infusion pharmacy, serving clients who require clotting factor
, IVIg and other medications for complex chronic conditions.
The missing clotting factor
is injected into the bloodstream using a needle.
Infusing a crystalloid solution (normal saline or lactated Ringer's solution) or stored packed red blood cells without clotting factors
into a hemorrhaging patient will dilute the clotting factors
and can actually make the patient more coagulopathic.
FFP thawed at high temperatures may denature clotting factors
but no study has addressed the postulate of clotting factor
activation in FFP thawed at high temperatures.
Consequently, military trauma teams have turned their focus to aggressively replacing clotting factors
with FFP, cryoprecipitate, and, when necessary, recombinant activated clotting factor
VII (rF-VIIa) early in resuscitation.
In its bite, the tiger keelback delivers slow-acting salivary toxins, which disable a clotting factor
in the blood of its victims.
Several patients continued to use less clotting factor
after combination therapy stopped.
By all accounts, this represents a dramatic reduction in the amount of reimbursement that provides for blood clotting factor
and a few ancillary supplies.
In 2001, Medicare's outpatient expenditures for blood clotting factor
used to treat the estimated 1,100 beneficiaries with hemophilia totaled about $105 million, or more than 2 percent of total Medicare spending on outpatient drugs.
This project will determine whether blood clotting factor
homologues are expressed in fiber type-specific muscle exposed to the atrophy of simulated microgravity.
Gene therapy appears to partially correct hemophilia in dogs while avoiding an immune reaction that can destroy the life-saving replacement clotting factor
used to treat the disease.