The CLOCK gene
has an important role in regulating many rhythmic patterns of the body, including body temperature or level of cortisol, the primary stress hormone.
They found that anaesthesia administration suppressed clock gene
expression at investigated single time point.
In liver, L-DOPA did not affect the rhythmicity and expression of these clock genes
(P > 0.
Our results show that corals have significant differences in clock gene
transcription over the course of a synodic lunar cycle, and that the stability of these changes requires a normal pattern of lunar illumination.
There is a link between clock gene
expression and sleep-related processes; however the underlying regions supporting sleep homeostasis have received relatively limited focus.
Thus, melatonin is important in the regulation of the expression of clock genes
especially in the ganglion cells layer and less so in the photoreceptors.
More relevant to this research is the fact that PER3 and its length polymorphism may have a role in the formation of tumors since clock genes
are the main regulators of cell cycle and DNA repair pathways, according to the Argentinian research team.
Neonatal alcohol exposure differentially alters clock gene
oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats.
Animal studies reveal that the Clock gene
controls the length of a period in a free-running rhythm and it allows an organism to maintain circadian rhythmicity in total darkness.
311 1T/C clock gene
polymorphism is not associated with sleep disturbances in untreated depressed patients.
Moreover, positive modulation of clock gene
expression leads to improved cellular metabolism as assessed by a 33% increase in collagen III production.
New interest in the role of circadian dysregulation in psychiatric disorders has arisen from the finding that a mutation in a core circadian clock gene
induces hyperactivity, decreased sleep, and mania-like behavior in mice.
Regulation of dopaminergic transmission and cocaine reward by the Clock gene
Circadian rhythms of melatonin, cortisol, and clock gene
expression during simulated night shift work.
Expression of the circadian clock gene
Period 1 in neuroendocrine cells: An investigation using mice with a Per1::GFP transgene.