SAN FRANCISCO -- Antiretroviral therapy has allowed many HIV-infected people to live long enough to grow old, yet their immune systems seem to age rapidly for their chronologic age
, a factor that appears to be contributing to increased risks for non-HIV diseases of aging in middle-aged patients, according to several speakers at a meeting on the medical management of HIV and AIDS sponsored by the University of California, San Francisco.
It may also help to identify individuals or subgroups among the heterogeneous older adult population that might be susceptible to environmental agents because it has been shown to be a better predictor of adverse outcomes in older adults than chronologic age
(Schuurmans et al.
It does not take into account a family history of coronary heart disease, and it relies on a person's chronologic age
rather than their biologic age.
Age referred to chronologic age
(in completed months) at the time of the NHANES III exam and was converted (divided by 12) to years for analysis.
But not all individuals of the same chronologic age
have the same life expectancy.
Restriction criteria for entering the study were a chronologic age
of 5 years at the time of the study, Romanian speakers, the absence of significant previous neurologic sequella such as polio and head injury, the absence of a known chelated case of lead poisoning, no severe malnutrition and anemia, and a birth weight of [greater than or equal to] 2,000 g; in the assumed high-exposure cohort or cases, the restriction criteria also included a clinically diagnosed case of infantile MHG.
I think the bottom line here is, we have to look at physiologic age as well as chronologic age
And because the rate of physiologic decline can vary markedly among individuals, chronologic age
is not a reliable index of vulnerability.
By substituting vascular age for chronologic age
in the standard Framingham 10-year risk score calculation, Dr.
Developmental processes in early adolescence: relationships between adolescent adjustment problems and chronologic age
, pubertal stage and puberty-related serum hormone levels.