The concentrations studied were not mutagenic on the in vivo onion root-tip cells as witnessed by the fact that despite the large number of cells assessed there were no visible chromosome aberrations
in either the treated or negative control cells.
The chromosome aberration
test is another hot topic in the genotoxicity field.
In the present study, we have investigated the clastogenic effects of agricultural and home made waste contaminants of the Alahad municipality on the formation of micronucleus and chromosome aberrations
on Allium cepa root tip.
Rank J and M Nielsen Genetoxicity Testing of Wastewater Sludge using the Allium cepa Anaphase-telophase chromosome Aberration
2003, "The method of Allium anaphase-telophase chromosome aberration
assay," Ekologia, 38-42.
Results: Chromosomal abnormalities, including novel chromosome aberrations
were detected in 54.
A comparison of 8-hydroxydeoxyguanosine, chromosome aberrations
and micronucleus techniques for the assessment of the genotoxicity of mercury compounds in human blood lymphocytes.
Spontaneous sister chromatid exchange and chromosome aberration
frequency in humans: the familial effect.
Others range from pathology and hematology (quantitative genetic scoring of tissue sections from solid tumors or from bone marrow preparations; virtual slide imaging; rare tumor cell detection) to toxicology (DNA damage assessment using the micronucleus test or Comet assay; chromosome aberration
testing and automatic scoring of dicentric chromosomes) and even to forensic science (automatic sperm detection in material from crime scenes).
type (mean [+ or -] SE) (a) Genotype (n) Aberrant cells XPD-312 Asp/Asp (27) 09.
BioReliance Laboratories of Rockville, Maryland conducted multiple in vitro chromosome aberration
screening assays of various concentrations of Zeatin, the first one in Chinese hamster ovary cells and the most recent one in human peripheral blood lymphocytes.
Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration
end aister-chromatid exchange analysis in peripheral blood lymphocytes.
In an in vitro chromosome aberration
assay, when Chinese hamster ovary cells were treated with high concentrations (450-550 micromol) of finasteride, there was a slight increase in chromosome aberrations
Imiquimod was without effect in a series of eight different mutagenicity assays including Ames, mouse lymphoma, CHO chromosome aberration
, human lymphocyte chromosome aberration
, SHE cell transformation, rat and hamster bone marrow cytogenetics, and mouse dominant lethal test.
Although urinary 2,4-D levels were not correlated with chromosome aberration
frequency, chromosome aberration
frequencies were correlated with the total volume of herbicides applied, including products other than 2,4-D.