We aimed: (i) to detect CMV infection rates and baseline characteristics of infants with BA over 10 years (2001-2011); and (ii) to investigate the effect of perinatal CMV infection in BA and compare the outcomes of CMV-IgM-positive children with non-exposed children with cholestatic jaundice
After excluding right ventricular failure, biliary obstruction, superin fection, and hepatocellular carcinoma, the marked cholestatic jaundice
was thought to be caused by thyrotoxicosis.
Often, cholestatic jaundice
caused by intrahepatic hepatocellular disease may be clinically and biochemically indistinguishable from cholestasis due to extrahepatic bile duct obstruction.
In this issue of the Journal, Lowe et al (6) report the case of a 66-year-old white male who presented with cholestatic jaundice
and a 30 pound weight loss over the preceding 2 months.
Cases of cholestatic jaundice
with minimal elevation of transaminase levels have also been reported.
They include nausea, dizziness, fatigue, shortness of breath, skin rash, nervousness, toxic hepatitis, cholestatic jaundice
, nephrotoxicity, and psychosis, particularly with prolonged therapy.
Discontinue estrogen if severe hypercalcemia, loss of vision, severe hypertriglyceridemia or cholestatic jaundice
The condition then manifests as cholestatic jaundice
in the first few weeks after birth.