Differential modulation of synaptic transmission by calcium chelators
in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging.
The researchers analyzed the concentrations of iron and copper in white wine and also measured the amount of oxidation that occurred after the chelators
were added to samples.
We compared 2 NTBI assays: a labile plasma iron (LPI) assay that uses desferrioxamine as the iron chelator
(3) and a microwell modification of a bleomycin-detectable iron (BDI) assay (2).
Brightly coloured fruits and vegetables are good sources of iron chelators
And the results with natural seawater show this also occurs with natural chelators
," says Sunda.
The researchers found that removing metals, hampers both amyloid beta clumping and the production of those harmful reactive oxygen species, suggesting that chelators
could be useful in treating Alzheimer's disease.
Deferasirox and deferiprone are two orally-active iron chelators
that have been approved for clinical use, but they are not yet easily accessible to all patients .
However, B(6) vitamers were most effective at preventing oxidative stress or lipid peroxidation cytotoxicity suggesting that pyridoxal or pyridoxal phosphate were antioxidants and/or Fe/Cu chelators
BMC Genomics 8: 379, 2007; Biochmica Biophysica Acta 1619: 113-24, 2003) Middle-aged males and postmenopausal females have accumulated stores of excess iron and calcium which can be removed by natural mineral chelators
, like those provided in Longevinex.
Most doctors of integrative medicine who use NAC also add other chelators
and detoxifiers, such as alpha lipoic acid, glutathione, and glycine.
A non-toxic chelation agent, such as MCP, could be used safely for prolonged periods and may be an important chelation treatment alternative for children exposed to lead on an ongoing basis, as well as people for which conventional chelators
We want chelators
that are specific for our [radioactive] metals of interest" but that don't bind to others, such as calcium, which is a major ingredient of concrete and marble, says Mark E.
produced by the fungi likely play a role in non-enzymatic wood decay processes since enzymes have been shown to be too large for initial wood cell wall penetration (Srebotnik et al.
Over 130 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators
, ion channel modulators and gene therapy.
Many soil fungi normally produce a variety of compounds that behave as chelators