prior to operative procedures makes the operation easier and decreases the risk of cervical injury and uterine perforation which are often associated with mechanical cervical dilatation.
Ruth Ann Word, MD, of the University of Texas Southwestern Medical Center in Dallas, is trying to determine how body chemicals called prostaglandins control cervical ripening
4]] Prostaglandins have been shown to be efficacious in both cervical ripening
and labour induction.
A recently study compared the efficacy of various routes of single dose of 400 mcg misoprostol in cervical ripening
and demonstrated that the mean time from induction to abortion, intraoperative pain score and duration of surgical evacuation in sublingual group was significantly lower than vaginal and oral routes.
Misoprostol, a PGE1 analogue, has been reported to be an effective and affordable cervical ripening
and medical induction agent.
The immune system or inflammatory response is sufficient to cause cervical ripening
, but it's not absolutely necessary for it to happen," points out Brenda Timmons, research scientist in obstetrics and gynecology and co-lead author of the study.
Buccal versus intravaginal misoprostol administration for cervical ripening
Complications of cervical ripening
agents vary according to pharmaceutical agent used, the dose and the fetal/ maternal context (Sanchez-Ramos and Hsieh, 2003).
Use of a Foley catheter for cervical ripening
in situations where the cervix is unfavourable is associated with a lower chance of success but no increased risk of uterine rupture.
It should only be used in pregnancy for its off-label indications: uterine stimulation and cervical ripening
In November of 2004, the Tatia Oden French Memorial Foundation presented a petition to the Food and Drug Administration, demanding a more complete review of the hazards of Cytotec (Misoprostol), especially in regard to labor induction and cervical ripening
In France, mifepristone is registered for use for cervical ripening
prior to surgical abortion.
BACKGROUND Cervical ripening
during parturition is a dramatic process of tissue remodeling that produces drastic changes in the biomechanical properties of the tissue.
Davenport's use of prostaglandin gel in an in-house composition for cervical ripening
after the Pharmacy & Therapeutics Committee had instructed the OB/ GYN Department against doing so.
It also warns, "In addition to the known and unknown acute risks to mother and fetus, the effect of Cytotec on the later growth, development, and functional maturation of the child when Cytotec is used for induction of labor or cervical ripening
has not been established.