3) We believed that our patient's tumor might have malignant potential because of (1) the infiltration of the capsule without infiltration of adjacent tissues, (2) the widespread central necrosis
, (6) and (3) the Ki-67 value of 5 to 10%.
In addition, intravital microscopy using a murine pseudo-orthotopic breast cancer model showed that NPI-2358 induces a rapid decrease in tumor blood flow resulting in tumor vascular collapse and central necrosis
in established tumors.
The histologic features included an infiltrative proliferation of cords and nests of epithelial cells extending throughout the skin to the deep dermis or subcutis, along with a characteristic zonation of cytologic features, including peripheral squamous cells, intermediate clear cells, and central necrosis
A computed tomography (CT) scan of the abdomen revealed a 15-cm left renal cell carcinoma (RCC) with central necrosis
and left renal vein and regional lymph nodes involvement.
6) Tumors with rapid growth and central necrosis
also frequently exhibit intense T2 weighted signals.
frequently develops as the "tumor mass" increases in size.
The mediastinal lymph nodes were also strongly positive, accompanied by central necrosis
Histopathology showed anaplastic tumor cells arranged in irregular, lobular formation with central necrosis
giving it a comedo pattern.
MN-029 selectively disrupts newly-formed tumor blood vessels, shutting down tumor blood flow and causing central necrosis
of solid tumors.