cytotoxicity

(redirected from cell-mediated cytotoxicity)
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  • noun

Words related to cytotoxicity

the degree to which something is toxic to living cells

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References in periodicals archive ?
Bottino, “Antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to augment the efficacy of IgG1 mAb therapeutics (eg.
Results: [gamma][delta] T cell-mediated cytotoxicity is inhibited by blocking PI3-kinase with wortmannin or LY294002.
Our study also discusses these agents and technologies, among others: - Site-specific linkers - Glycosylation or glycoengineering - Defucosylation - Amino acid modification - Enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) - Bispecific, trispecific and multi-specific antibodies - Domain fragments - Single-chain variable fragments - Alternative scaffolds: DARPins, anticalins, Affibodies, Fynomers, Affilins, Adnectins and i-bodies - Combination therapies - Other novel antibody platforms Next-generation antibody therapy R&D is strong in antibody-drug conjugates.
further enhance the therapeutic properties of SIMPLE Antibody leads in terms of tissue penetration/residence time in the body, ability to clear disease targets or pathogenic antibodies and cell-killing potency through Antibody-Dependent Cell-mediated Cytotoxicity (ADCC), respectively.
further enhance the therapeutic properties of SIMPLE Antibody(TM) leads in terms of tissue penetration/residence time in the body, ability to clear disease targets or pathogenic antibodies and cell-killing potency through Antibody-Dependent Cell-mediated Cytotoxicity (ADCC), respectively.
further enhance the therapeutic properties of SIMPLE Antibody(TM) leads in terms of their residence time in the body, their ability to clear disease targets or pathogenic antibodies and their cell killing potency through Antibody-Dependent Cell-mediated Cytotoxicity (ADCC), respectively.
PEGPH20, by removing HA from the cancer cell surface, potentially allows greater contact of NK cells to tumor cells, a key process involved in antibody-dependent cell-mediated cytotoxicity of cancer cells.
Antibody technologies: Chimeric, fully human, humanized, pegylation, Fab fragment, Fc engineering, glycoengineering, antibody drug conjugate (ADC), bispecific antibody, naked antibody, pretargeted radioimmmunotherapy (PT-RAIT), cell-killing agents, cytotoxic agent, toxin, tumor-targeted superantigens (TTS), antibody-dependent cell-mediated cytotoxicity (ADCC) enhancing, complement-dependent cytotoxicity (CDC) enhancing, inhibiting and activating Fc receptors, defucosylation, isotype chimerism, production systems, glycosidase inhibitors, sugar engineering, Fab arm switching or Fab crossover, trifunctional, bispecific T cell engager (BiTE), dual-variable-domain immunoglobulin (DVD-Ig), TandAb, dock and lock (DNL) technology, dual-affinity re-targeting (DART).
Subsequently, Genmab has collected data that appears to show HuMax-CD20 is also effective in inducing Natural Killer cell-mediated cytotoxicity of B-cell tumors.