Topline results from the ten ileostomized participants who completed the Phase 2a open-label study demonstrated that SYN-004 successfully degraded residual IV ceftriaxone
in the chyme (digestive fluid in the small intestine) without affecting the intended level of ceftriaxone
in the bloodstream.
Before the new strain in 2013 was discovered, ceftriaxone
was the only drug effective enough to treat gonorrhoea.
resistance was mobilized to Escherichia coli by conjugation at a frequency 6.
In addition to culture-based susceptibility testing, three molecular assays were carried out to detect the gyrA gene, (associated with ciprofloxacin resistance), the penicillin resistance plasmid found in PPNG, and the mosaic penA sequence (associated with reduced ceftriaxone
One patient receiving ceftriaxone
had unexplained hepatitis, with negative viral studies.
was effective for all of them except the Prevotella, while metronidazole was effective against only the Prevotella.
treats inflammatory infections of the organs of the abdominal cavity, including peritonitis, as well as, inflammatory diseases of the gastrointestinal and bile- excreting tracts.
appears to block craving by reversing the decrease in GLT1 caused by repeated exposure to cocaine.
, an antiobiotic, has been reported to cause biliary pseudolithiasis and nephrolithiasis, but postrenal acute renal failure was rarely reported in the past.
Not only have we had to increase the recommended dosage of ceftriaxone
, but now this is our therapy of last resort," she said.
These isolates can also be considered susceptible to amoxicillin and ceftriaxone
Key Words: Salmonella, hemoglobinopathies, sickle cell, ceftriaxone
resistance, bacteremia, osteomyelitis, psoas abscess.
Amoxicillin, ampicillin, cefepime, cefotaxime, ceftriaxone
, cefuroxime, ertapenem, imipenem, and meropenem must be tested by a MIC method.
One of these antibiotics, ceftriaxone
, showed particularly promising results.
The CDC now recommends that men who have sex with men (MSM) be treated with either ceftriaxone
125 mg intramuscularly or cefixime 400 mg orally (not currently available in the United States): Spectinomycin 2 g intramuscularly is an alternative (MMWR 53:335-38, 2004).