Third generation cephalosporins such as ceftriaxone, ceftazidime
and cefotaxime are used as blind therapy in our institution, especially in suspected cases of septicemia.
Comparison of different phenotypic tests for detection of MBL producing isolates Phenotypic test Number of MBL positive isolates (n=21) Modified Hodge test on Mueller Hinton Agar 15 Modified Hodge test on MacConkey Agar 19 Combined Ceftazidime
+ EDTA 8 disc test Imipenem + EDTA 20 Double disc synergy test 20 EDTA-Imipenem microbiological assay 20 Extended EDTA Ceftazidime
12 disc synergy Imipenem 20 test Meropenem 18 n, number of screen positive isolates tested
Treatment Sonnenwirth, 1970 (6) Penicillin Barbaro et al, 1987 (7) Cefoxitin; drainage then ampicillin, gentamicin, clindamycin Moxalactam, nafcillin Cefoxitin Ampicillin, clindamycin, tobramycin Cefoxitin Cefoxitin None Ampicillin Cefoxitin Ampicillin NR NR NR NR NR NR Horowitz et al, 1990 (4) Ciprofloxacin, ceftazidime
Franzetti et al, 1992 (3) Ceftazidime
Castagnola et al, 1994 (5) Ceftazidime
, vancomycin, amikacin Ender et al, 1996 (8) Ceftazidime
, ciprofloxacin Isotalo et al, 2000 (2) Cefazolin, gentamicin Present case Lovofloxacin Series (ref.
Keywords: Alpinia officinarum Hance Galangin Quercetin Baicalein The synergism with ceftazidime
Penicillin-resistant Staphylococcus aureus
ESBL screening and confirmation by phenotypic methods: The isolates showing reduced susceptibility to ceftazidime
or cefotaxime or both were tested for ESBL production by double disk-diffusion test (DDDT) using four disks (p.
versus aztreonam in the treatment of pseudomonal chronic suppurative otitis media in children.
The study met its objectives of assessing safety and efficacy of CXA-101 in comparison to ceftazidime
The addition of avibactam protects ceftazidime
from being broken down by certain beta-lactamases that are produced by these resistant bacteria.
Treatment was changed to ceftazidime
(120 mg/kg/d) trimethoprim/sulfamethoxazole (TMP/SMX) (10/50 mg/kg/d) and oral doxycycline (200 m/d) for 3 weeks.
Antimicrobial discs used were ampicillin (10), amoxycillin/clavulanic acid (10/20), piperacillin (100), piperacillin/tazobactem (100), ticarcillin (75), ticarcillin/clavulanic acid (75/10), cefixime (5), cefuroxime (30), cefpodoxime (10), cephotaxime (30), ceftazidime
(30), aztreonam (30), netilmycin (30), amikacin (30), gentamycin (30), chlorophenicol (30), co-trimoxazol (30), tetracycline (30), imipenam (10) and meropenam (10).
Some of the antibiotics that were used were nebulized already (levofloxacin, ofloxacin, and ciprofloxacin); others were compounded for nebulization (tobramycin, ceftazidime
, and gentamicin).
If an obvious Pseudomonas aeruginosa infection is present, antipseudomonal antibiotics, such as ciprofloxacin, ceftazidime
, or ticarcillin/clavulanic acid are administered.
NEW YORK -- Forest Laboratories (NYSE:FRX) announced today its agreement to acquire additional rights to NXL 104, which amends the terms of its prior agreement with Novexel covering the combination of NXL 104 with ceftaroline and adds additional rights to the combination of ceftazidime
and NXL 104, through a transaction with AstraZeneca executed immediately following AstraZeneca's announced acquisition of Novexel, S.
AVYCAZ is contraindicated in patients with known serious hypersensitivity to AVYCAZ, avibactam containing products, ceftazidime
, or other members of the cephalosporin class.
, ceftriaxone, or cefotaxime) associated with production of extended-spectrum [beta]-lactamases (ESBLs) limits therapeutic options (3).