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More than 300,000 Americans die annually from congestive heart failure, usually within five years of diagnosis, because cardiac muscle has little or no capacity for self-repair and current treatments are often inadequate.
They went on to show that cardionogen could stimulate mouse embryonic stem cells to differentiation into beating cardiac muscle cells.
Mammalian tissue sources for harvesting PPMSCs have included skeletal and cardiac muscle, wound tissue, skin, marrow, and periosteum.
These results highlight one of the putative mechanisms of action by which fresh, uncultured adipose stem cells contribute to the repair of damaged cardiac muscle, specifically the angiogenic effects," Milstein said.
Experiments in animal models of several important diseases also found that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets.
The review highlights the proposed mechanisms by which adipose stem cells contribute to the repair of damaged cardiac muscle, specifically the angiogenic effects and the prevention of cell death as primary mechanisms as well as differentiation into new cardiac muscle.
Also of significance is the fact that, while the antibody is known to bind to some peripheral nerve cells and cardiac muscle, we have observed no cardiac or neurological toxicity related to administration of the drug.
These results are in contrast to studies by others using adult bone marrow-derived hematopoietic or skeletal myoblast stem cells which do not produce new cardiac muscle tissue after injection into infarcted hearts.
Specifically, the team found that their intervention halted transforming growth factor beta (TGF-beta) secretion at a precise location called cell receptor type 2 in cardiac muscle cells.
Too often, those who have lost cardiac muscle go on to develop congestive heart failure as a result of lost muscle mass after a heart attack.
It was also unknown which of the proteins in the cardiac muscle is the target of these fatal immune attacks.
These cells have been shown to reduce the extent of a heart attack and promote restoration of heart function by a variety of mechanisms, including promotion of blood vessel growth and differentiation into cardiac muscle tissue.
Washington, Dec 10 (ANI): Worcester Polytechnic Institute (WPI) researchers have demonstrated a new way that could be used to deliver stem cells to targeted areas of the body to repair diseased or damaged tissue, including cardiac muscle damaged by a heart attack.
hERG: Technology and Market Analysis focuses on hERG, a potassium channel that is abundant in the cardiac muscle.
Duchenne muscular dystrophy is a genetic disease that causes progressive muscle weakness, and usually leads to death by the age of twenty from respiratory or cardiac muscle failure.