AT982 consists of an AAV8 vector that delivers a GAA gene expression cassette containing a novel hybrid promoter designed to increase GAA activity in targeted tissues, including skeletal and cardiac muscle
, the nervous system and the liver.
They release an array of biomolecules following intra-myocardial administration that act to both dampen damaging inflammatory processes and initiate reparative processes in the failing heart through new blood vessel formation, cardiac muscle
cell growth, and reduction in fibrosis and scar.
These pressures, created by the contraction of cardiac muscle
in the ventricle walls, control the opening and closing of the semilunar valves and thus the movement of blood from the left and right ventricles into the aorta and pulmonary trunk.
This study showed and induced structural changes in the heart ventricle tissues indicating a negative impact on the capacity of the cardiac muscle
for pumping blood and may cause heart attack due to accumulation of free radicals and tissue inflammation.
When the cardiac muscle
is compromised and cells die, it can often lead to death.
An impulse-conducting system of the heart for initiation and propagation of electrical impulses for cardiac muscle
contraction It is formed by highly specialized cardiac muscle
cells (Purkinje fibers), which generate and conduct electrical impulses rapidly through the heart.
Daniel-Constantin Manolescu, the first author of the study asserted that in obese and insulin resistant mice, retinoic acid reduced the risk of cardiac apoptosis, stimulated the expression of cardio-protective genes reduced by the disease, and protected against the accumulation of collagen in the cardiac muscle
, which avoided the occurrence of fibrosis and possible associated future complications.
In cardiac muscle
, a transient increase in cellular Ca concentration occurs in response to regular electrical signals produced by pacemaker cells.
The term "cardiopoiesis" refers to the production of cardiac muscle
A team of Harvard University researchers has transplanted artificial cardiac muscle
cells developed from multipurpose stem cells into six heart-failure patients in the United States in the world's first clinical application of such cells, one of the researchers said Wednesday.
Organization of 108 chapters is in sections on cardiac muscle
(basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease).
1] So Serum enzyme AST and protein troponin I are the best indicators for cardiac muscle
injury because of their early rise, i.
Because we can't replace lost cardiac muscle
, the condition irreversibly leads to a decline in heart function and ultimately death.
Compared with a healthy hawk, concentrations were elevated by a factor of 50 in the kidneys, 37 in skeletal muscle, and 18 in cardiac muscle
Changes in other markers suggested that PE may inhibit collage hyperplasia, lessen the interstitial fibrosis of cardiac muscle
and increase compliance of cardiac muscle
to improve the heart's diastolic function in AMI rats.