Interestingly, these events occur at nontoxic (nanomolar) concentrations, well below the concentrations of any reported toxic complications encountered with therapeutic cardiac glycoside
Eddleston M, Ariaratnam CA, Sjostrom L, Jayalath S, Rajakanthan K, Rajapakse S, Colbert D, Meyer WP, Perera G, Attapattu S, Kularatne SAM, Sheriff MR and DA Warell Acute yellow oleander poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside
concentrations on presentation to hospital.
2+] release as suggested for some actions of cardiac glycosides
(McGarry and Williams 1993; Nishio et al.
Endogenous cardiac glycosides
, a new class of steroid hormones.
He and co-workers have already begun a multicenter study involving 300 people with congestive heart failure, in search of a link between potentially fatal digitalis toxicity and circulating levels of the ouabain-like cardiac glycoside
ATPase and identification of a new region involved in cardiac glycoside
The third application is for "Compositions and Methods Using a Cardiac Glycoside
Most patients in the clinical trial supporting effectiveness, referred to as the African American Heart Failure Trial (A-HeFT), received, in addition to BiDil or placebo, a loop diuretic, an angiotensin converting enzyme inhibitor or an angiotensin receptor blocker, and a beta blocker, and many also received a cardiac glycoside
or an aldosterone antagonist.
Both EIAs were based on the competitive binding of free cardiac glycosides
(ouabain/dihydroouabain) or free mammalian cardenolides (OLF/Dh-OLF) in the sample and bound cardiac glycoside
to a constant amount of the respective antibodies in the EIAs.
ATPase and determinants of cardiac glycoside
Detection of poisoning by plant-origin cardiac glycoside
with the Abbott TDx analyzer.
Digoxin is a purified cardiac glycoside
extracted from the foxglove plant, Digitalis lanata.
This drug is the most slowly excreted cardiac glycoside
, with a half-life of 4 to 10 days .
High-affinity monoclonal antibodies to the cardiac glycoside
CHAPTER FOUR: PRESCRIPTION CARDIAC GLYCOSIDE
AND IONTROPIC DRUGS Overview of Cardiac Glycosides
and Inotropic Drugs