affects elderly females and would evidently display a biphasic pattern, associated usually with high-grade carcinomatous component, most frequently serous carcinoma, and a pleomorphic, typically spindle-cell sarcomatous component.
This tumor possesses the histopathologic features of both teratomas and carcinosarcomas
Skin metastasis from the spindle cell component in rectal carcinosarcoma
most commonly arise from the uterus, ovaries, fallopian tubes and vagina in descending order of frequency (3), it seems safe to assume that when they are located elsewhere in the body they are also more likely to be in women, as was the case here.
7), (8) Meyer (1920) classified carcinosarcomas
into three histogenetic groups: 1) collision tumors in which carcinoma and sarcoma arise simultaneously in proximity and subsequently invade each other, 2) combination tumors in which both tumors derive from pluripotent cells, and 3) composition tumors in which the components arise from the same tissue.
Malignant biphasic uterine tumors: carcinosarcomas
or metaplastic carcinomas?
The type II samples included tumors of squamous, uterine serous carcinoma, clear cell, mucinous, and carcinosarcoma
with osteogenic components are extremely uncommon, with about 40 cases reported in the literature.
(CS) are neoplasms characterized by the presence of both malignant epithelial and mesenchymal components.
1-6) True carcinosarcomas
of the larynx and the hypopharynx represent less than 1% of all malignant neoplasms in this area.
Abstract #3999: "Molecular characterization of 361 cases of uterine carcinosarcomas
reveal alterations in the DNA repair and PI3K pathways as potential therapeutic targets," presented by Nathaniel L.
Two main theories exist on the origin of carcinosarcomas
1-15) All of these cutaneous carcinosarcomas
had developed in patients who were older than 40 years, and most of them behaved in a manner that was clinically less aggressive than the progression of carcinosarcomas
at other sites.
Genomic analyses of gynaecologic carcinosarcomas
reveal frequent mutations in chromatin remodelling genes, Sian Jones, Nicolas Stransky, Christine L.
Because of the spindle cells and giant cells, these tumors are often mistaken for sarcomas or carcinosarcomas