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47,48) Mucinous differentiation in mixed subtype of adenocarcinomas and mucinous bronchioalveolar carcinoma has also been shown to correlate with a higher frequency of KRAS mutation.
HER2/neu mutations have been reported in approximately 4% of NSCLCs, very similar to EGFR mutations, seen in never smoking women with adenocarcinoma exhibiting predominant bronchioalveolar carcinoma pattern.
Resmycin received Fast Track designation by the FDA for the treatment of Bronchioalveolar Carcinoma, a type of lung cancer, which may allow BPT to file a New Drug Application with Phase II data.
Also already underway is a two-arm, randomized, Phase II study of VELCADE in combination with erlotinib for patients with locally advanced or metastatic NSCLC and a study of single-agent VELCADE in relapsed bronchioalveolar carcinoma and adenocarcinoma of the lung.
Dasgupta said this study focused on a specific type of lung cancer called bronchioalveolar carcinomas, or BACs, which are known to be associated with smoking.