The same mass would arrive in the bladder whether the modeled exposure was from small bolus doses
spread out over a period of time prior to the void event or from one large bolus dose
at a single time before the void event.
Recent studies with abciximab, which is a commonly used GP IIb/IIIa antagonist, have showed that intracoronary (IC) bolus dose
is more effective than IV bolus dose
in reducing major adverse cardiac events (MACE) in STEMI (4).
What is the degree of relative adrenal insufficiency in the patient receiving a bolus dose
The bolus doses
associated with the severe reactions have ranged from several 1,000 U of heparin to 40,000- to 50,000-U doses, Dr.
Of the patients who received optimal infusion doses, one did not receive a bolus dose
and the other received a suboptimal bolus dose
Butwick et al (18) randomised 75 patients undergoing elective caesarean section to one of four bolus doses
(0 [placebo], 0.
max] value for dietary exposure consistent with the oral bolus dose
of 20 mg/kg BW [i.
Recent advances have incorporated a continuous glucose monitor into the system along with algorithms that estimate the bolus dose
, but the technology still requires user input--and therefore is subject to some degree of error.
The bolus dose
was added to the infusion when calculating the mean daily infusion rate of the medication (midazolam or dexmedetomidine).
They were randomized to receive 1 of 3 regimens: a placebo bolus followed by a placebo infusion or a bolus dose
of eptifibatide followed by 1 of 2 eptifibatide infusions.
The bolus dose
usually creates a rather sudden, dramatic change while the chronic infusion allows for slower, milder, more controlled changes during the titration phase.
Following administration of the initial bolus dose
of the study drug, the design of this trial allowed a limited number of supplemental doses to be administered as required to initiate or maintain sedation during the procedure.
However, the pharmacokinetic characteristics of oxycodone administered as a subcutaneous bolus dose
in either critically ill or healthy populations have not been previously published.
Researchers noted that the number of patients receiving additional oxytocics was high in both groups, and this was most likely due to the prevailing routine at the hospital of giving an intravenous infusion of oxytocin following the initial bolus dose
Results: Dexmedetomidine was administered by continuous infusion to three patients and as a single bolus dose