Although the drug did affect differentiation into blood-vessel
cells, "we found that Avastin does not alter that first process whatsoever," said Tabar.
BIBN 4096 BS intervenes by displacing CGRP where it attaches to blood-vessel
and nerve cells.
However, when a mixture of the blood-vessel
widening drug and vitamin C was injected, blood flow jumped 60 percent in diabetics, according to the study, published this week in The Journal of Clinical Investigation.
An additional 600,000 cases are treated with coronary-bypass surgery that employs blood-vessel
grafts to route blood flow around blocked arteries.
However, sometimes the process goes into overdrive, causing smooth muscle cells from inside the blood-vessel
wall to multiply and pile up inside the stent.
Other research has suggested that nitric oxide may make blood cells less likely to adhere to blood-vessel