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Inside Insulin: 5 Sets of Facts, Figures, and Findings : This concise slide show summarizes new research on the use of premixed biphasic insulin and the impact on nocturnal hypoglycemia of investigational U300 insulin glargine.
For patients who had started on biphasic insulin, a midday prandial dose was added.
The mean recovery of compounds was consistent, being 101 per cent for regular insulin and 82 per cent for regular insulin in biphasic insulin.
The only products that address both basal and postprandial insulin deficiencies are premixed insulins, such as NPH and regular human insulin premix (Humulin or Novolin 70/30), or the biphasic insulin analog formulations [biphasic insulin lispro (Humalog Mix 75/25) and biphasic insulin aspart (Novolog Mix 70/30)].
and biphasic insulin aspart 30, both administered twice-daily with or without oral antidiabetic drugs in adult patients with type 2 diabetes previously treated with premixed or self-mixed insulin either once- or twice-daily.
Using continious glucose monitoring to measure the frequency of low glucose values when using biphasic insulin aspart 30 compared with biphasic human insulin 30.
Over 75% of patients with type 2 diabetes reached target A1C by adding biphasic insulin aspart 70/30 to optimised metformin and pioglitazone treatment.
The insulin users were further subdivided into users of glargine, long-acting human insulin, biphasic analogue, or human biphasic insulin.
The researchers focussed on the safety and effectiveness of using the biphasic insulin, which contains both fast-acting and intermediate components, prescribed by family doctors and hospital consultants.
exenatide compared with twice-daily biphasic insulin aspart in patients with
3, 2013 /PRNewswire/ -- Data presented today at the World Diabetes Congress of the International Diabetes Federation (IDF) show that adults with type 2 diabetes achieved improved glycaemic control, significantly lower rates of overall and nocturnal confirmed hypoglycaemia for the full trial period, and a significantly lower rate of severe hypoglycaemia during the maintenance period (defined as week 16 onwards) with Ryzodeg compared to biphasic insulin aspart 30, both administered twice-daily[sup.
Greater decreases in mean glycated hemoglobin levels were seen in patients who were randomized to either biphasic insulin aspart twice daily or prandial insulin aspart three times daily, compared with basal insulin detemir once daily (or twice daily if needed).
those receiving biphasic insulin aspart gained an average of 2.
Premixes, such as biphasic insulin aspart 30, comprise a soluble, rapid-acting portion of insulin, which acts to cover meal-time glucose excursions, and a longer-acting insulin, usually in the form of protaminated analog in these formulations, which means it is released slowly and can therefore cover basal insulin needs.