encephalopathy

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England (2010) highlights that unbound unconjugated bilirubin (not attached to albumin) coupled with other risk factors, such as pre-term birth and low levels or lack of oxygen, may open up the blood-brain barrier, enabling the unconjugated bilirubin to enter the brain resulting in bilirubin encephalopathy.
When bilirubin rises to toxic levels, bilirubin encephalopathy and subsequent kernicterus can occur.
The overall aim of this guideline is to promote an approach that will reduce the frequency of severe neonatal hyperbilirubinemia and bilirubin encephalopathy and minimize the risk of unintended harm such as increased anxiety, decreased breastfeeding, or unnecessary treatment for the general population and excessive cost and waste.
Though his miracles can be grotesquely warped--a birth is marred by bilirubin encephalopathy, a gift of literacy steals the power of speech--they are all, inevitably, about life or power.
No evidence of severe hyperbilirubinemia (total bilirubin levels greater than 20 mg/dL) or acute or chronic bilirubin encephalopathy was observed among neonates in this study.