Detection of extended-spectrum beta-lactamases
by using Boronic acid as an AmpC beta-lactamase
inhibitor in clinical isolates of Klebsiella spp.
The vaborbactam component of Vabomere is a non-suicidal beta-lactamase
inhibitor that protects meropenem from degradation by certain serine beta-lactamases
such as Klebsiella pneumoniae carbapenemase.
Countrywide spread of community and hospital-acquired extended-spectrum beta-lactamase
(CTX-M-15)-producing Enterobacteriaceae in Lebanon.
Evaluation of extended spectrum beta-lactamase
mediated resistance in Esche-richia coli and Klebsiella in urinary tract infection at a tertiary care hospital.
Table-II: Antibiotic resistance of AmpC beta-lactamase
in a Klebsiella pneumoniae clinical isolate in Colombia.
1 Gram negative bacteria including Escherichia coli and Klebsiella pneumoniae produce resistance threat with the evolution of multiple resistance mechanisms like enzyme production resulting in extended spectrum beta-lactamases
, Amp C b-lactamases and now the carbapenemases especially metallo-beta-lactamases
Antibiotic resistance rates of extended spectrum beta-lactamase
producing Escherichia coli and Klebsiella spp.
Transcontinental importation into the UK of Escherichia coli expressing a plasmid-mediated AmpC-type betalactamase exposed during an outbreak of SHV-5 extended-spectrum beta-lactamase
in a Leeds hospital.
Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase
inhibitor has the potential for an expanded spectrum against multi-drug resistant bacteria and could be a much needed option for patients suffering from difficult-to-treat infections.
In Taiwan, the ESBL and AmpC beta-lactamase
producing Enterobacteriaceae have emerged as important pathogens in past few years.
the rapidly growing involvement of acquired AmpC beta-lactamase
and CTX-M enzymes (2-4).
Among the topics are recent trends in resistance to cell envelope-active antibacterial agents among key bacterial pathogens, viable screening targets related to the bacterial cell wall, the proliferation and significance of clinically relevant beta-lactamases
structure and function, siderophore conjugates, and the role of the cell membrane and cell wall in mechanisms of daptomycin resistance in Staphylococcus aureus.
Synthetic Biologics (NYSE MKT: SYN), a biotechnology company focused on the development of biologics for the prevention and treatment of serious infectious diseases, has commenced manufacturing of its proprietary oral beta-lactamase
enzyme 'SYN-004' for use in pre-clinical and clinical trials to target the prevention of Clostridium difficile (C.