Interactive effects between polymorphisms in the beta-adrenergic receptors
and longitudinal changes in obesity.
Beta-blocking drugs such as carvedilol reduce the heart's workload by blocking beta-adrenergic receptors
One of the enzyme's regulatory functions is to turn off beta-adrenergic receptors
- molecular 'switches' that drive heart contraction.
Use of a left ventricular assist device (LVAD) reverses the down regulation of beta-adrenergic receptors
that is characteristic of heart failure, according to an autopsy study reported in the August 21 issue of Circulation.
In prior presentations, Cytokinetics scientists presented results that demonstrate that cardiac myosin activators increase cardiac contractility without increasing intracellular calcium and without stimulating beta-adrenergic receptors
or inhibiting phosphodiesterase activity, mechanisms that may be arrhythmogenic and associated with other adverse clinical effects.