Cytokinetics' program is based on the hypothesis that activators of cardiac myosin may address certain mechanistic liabilities of existing pharmaceuticals by increasing cardiac contractility without increasing intracellular calcium and without stimulating beta-adrenergic
receptors or inhibiting phosphodiesterase activity, mechanisms that may be arrhythmogenic and associated with other adverse clinical effects.
Cytokinetics' program is based on the hypothesis that activators of cardiac myosin may address certain mechanistic liabilities of existing pharmaceuticals by increasing cardiac contractility without stimulating beta-adrenergic
receptors or inhibiting phosphodiesterase activity, and consequently, without increasing cardiac myocyte intracellular calcium, which has been associated with adverse clinical effects in heart failure patients.
Propranolol: In 19 normal volunteers receiving PROSCAR 5 mg/day for 10 days, PROSCAR did not affect the beta-adrenergic
blocking activity or plasma concentrations of propranolol enantiomers after a single dose of propranolol.
VA Palo Alto Health Care System: RDS Innovation Research Pilot Grant entitled "Improving Beta-adrenergic
Signaling in the Treatment of Cognitive Dysfunction, an in vivo Study in the Ts65Dn Mouse Model of Down Syndrome.
COMBIVENT Inhalation Aerosol and COMBIVENT RESPIMAT contain albuterol sulfate, a beta-adrenergic
sympathomimetic amine and, therefore, should be used with caution in patients with convulsive disorders, hyperthyroidism, or diabetes mellitus, and in patients who are unusually responsive to sympathomimetic amines.
Moreover, study findings reported that the effects of CXL-1020 were independent from Beta-Adrenergic
Receptor and ACE-inhibitor pathways.
Timoptic-XE is a non-selective beta-adrenergic
receptor blocking agent indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
The number of beta-adrenergic
receptors is reduced, usually with preservation of alpha-adrenergic receptors and circulating catecholamines, causing beta/alpha-adrenergic imbalance, diastolic hypertension, reduced total blood volume, and other manifestations (3).
Although some studies have investigated the functions of beta-adrenergic
receptors in affective disorders, there is little evidence about the polymorphisms of beta-adrenergic
receptors in major depressive disorder It is necessary to compare the difference of polymorphisms between patients and controls to investigate the susceptibility to major depressive disorder
ACE inhibitors/ARB antagonists, beta-adrenergic
receptor blocking agents, diuretics, and inotropic drugs are the medications available for the treatment of congestive heart failure.
After a MI, the beta-adrenergic
system gets activated due to excessive concentrations of catecholamines accumulating in the myocardium.
Autoantibody activation of beta-adrenergic
and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension: Receptor autoantibodies in orthostatic hypotension.
Receptor Antagonists (Beta Blockers)
receptor agonist modulation of skeletal muscle growth.
Data was analyzed in order to determine the percentage of patients who upon discharge received antiplatelet therapy, lipid-lowering therapy with a statin, angiotensin pathway blockade, and beta-adrenergic
blockade, consistent with current ACC/AHA guidelines and the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) core measures for acute myocardial infarction.