Their study aimed at understanding the nature of the immune attack on the insulin secreting beta cells
in the pancreas that lead to the development of Type 1 Diabetes.
These encapsulated beta cells
will sense a person's glucose levels and produce insulin as needed, while the barrier shields them from the body's autoimmune attack that initially triggered the onset of T1D.
mass dynamics in Zucker diabetic fatty rats, Rosiglitazone prevents the raise in net cell death.
This project extends our research in methods of quantifying beta cell
dynamics in type 2 diabetes to understand patient variability and the response to beta cell
-modifying therapies," said Dr.
This in turn upsets the ability of insulin-secreting beta cells
in the pancreas to monitor blood sugar levels.
GLP-1 may also increase beta cell
proliferation and insulin synthesis.
And what's more, the scientists discovered that the beta cell
regenerates cells around it when it dies.
KEY WORDS: arsenic, diabetes, insulin secretion, Nrf2, oxidative stress, pancreatic beta cells
The DEFEND-1 study is investigating the ability of otelixizumab to preserve beta cell
function, which may reduce the risk of both short- and long-term complications of the disease.
The team injected viruses bearing three genes into the mice, transforming a common pancreatic cell known as an exocrine cell into the much rarer beta cell
that makes insulin.
Dr Iain Frame, Diabetes UK's research manager, said: "This research demonstrates that there may have been a substantial improvement in beta cell
GLP-1 stimulates pancreatic beta cells
to increase the secretion of insulin, so GLP-1 has the potential to improve beta cell
Professor Chan's team used a doctored virus to carry the beta cell
gene into the mouse liver cells.
Symptoms of IDDM usually develop over a short period, although beta cell
destruction can begin months, even years, earlier.
Emerging diabetes drugs consider beta cell
mass and function as an important target