Toluidine blue (TB) is a basic dye that helps in identification of myeloid blasts showing differentiation towards basophils, which may be seen in acute basophilic leukemia, basophilic blast crisis of chronic myeloid leukemia (CML) and AML with basophilia.
acute basophilic leukemia and blast crisis of CML with basophilic differentiation.
AML with recurrent cytogenetic translocations AML with t(8;21)(q22;q22) Acute PML with t(15;17)(q22;q21) Variant acute PML with t(v;17) AML with abnormal bone marrow eosinophils inv(16)(p13;q22) or t(16;16)(p13;q22) AML with 11q23 abnormalities AML with multilineage dysplasia With prior myelodysplastic syndrome Without prior myelodysplastic syndrome AML and myelodysplastic syndrome, therapy related Alkylating agent related Topoisomerase II inhibitor related Other types AML not otherwise categorized AML minimally differentiated AML without maturation AML with maturation Acute myelomonocytic leukemia Acute monocytic leukemia Acute erythroid leukemia Acute megakaryocytic leukemia Acute basophilic leukemia
Acute panmyelosis with myelofibrosis Table 13.
The rare cases of acute basophilic leukemia
reported have frequently shown expression of common myeloid antigens such as CD13 and CD33, as well as CD9, CD11b, and CD123.
Previously, we reported that the structural requirements of the 3-phenylisocoumarins for inhibition of degranulation and/or release of TNF-[alpha] and IL-4 in rat basophilic leukemia
(RBL-2H3) cells (Wang et al.