The BCC is a common skin cancer that arises from the cells of the basal layer
of the epithelium or from the external root sheath of the hair follicle.
analysis from this study indicated that the basal layer
is responsible for the renewal of keratinocytes, that are in constant mitosis and originate the spiny and granular layers (Figs.
From these observations, it may be added that besides the size of amyloid deposition, prominent hyperkeratosis, acanthosis and papillomatosis, other features like increased basal layer
pigmentation and pigment incontinence (both more frequent in macular amyloidosis) as well as papillomatosis and periappendageal mononuclear and neutrophilic dermal infiltrate (more frequent in lichen amyloidosis) can be used for distinction between the two histologically.
Immunopositive cells stained for p53 were detected in the basal layer
of the lining epithelium.
In patients with DI-SCLE, the histological examination of a skin biopsy often indicates vacuolar degeneration of the epidermal basal layer
, necrotic keratinocytes, and lymphocytic interface dermatitis.
Histopathological examination revealed vacuolar degeneration on the basal layer
, melanophages, and lymphocytic infiltration in the upper dermis.
Localization of cytokeratin-14 in the basal layer
and presence of cytokeratin-10 in the supra-basal layers
verified an anatomically correct differentiation of the epidermis.
Microscopically hematoxylin and eosin stained section showed cystic lining of variable thickness with prominent hyperchromatic palisading basal layer
, along with proliferation of lining in form of plexiform strands (Figure 4).
Basal cell tumors arise from nonkeratinizing cells that originate in the basal layer
of the epidermis and are one of the most common skin tumors in domestic cats .
Strictly defined, the basal layer
extends to the point at which the nuclei are separated by a distance greater than the nuclear diameter (9) or when 50% of the cells are separated by a distance less than the width of one nucleus.
However, in the group treated with dexamethasone, the blastema developed less and the cells of the epithelium basal layer
were not yet cylindrical, which is an essential characteristic for the synthesis of the basal membrane (Figures 4 and 5).
This process ensures a balance of newly generated cells from the basal layer
, which pass upward through the spiny and granular layer, arriving in the stratum corneum where the cells spend the remaining half of their life before being desquamated.
Furthermore, changes in absolute volumes of individual components of the placenta: the labyrinth, the basal layer
, and the decidua were evaluated.
The research team grew pieces or "organoids" of esophageal tissue from mouse samples, and then conducted experiments to identify and track the different cells in the basal layer
of the tissue.
Obvious hyperplasia and hyperkeratosis in basal layer
and high mitotic index have made poor prognosis (figure 6).