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Aminoglycosides are potent bactericidal antibiotics targeting the bacterial ribosome, and the increase in cases of bacterial resistance to aminoglycosides is widely recognized as a serious health threat (11).
Daptomycin is a member of a new category of bactericidal antibiotics known as lipopeptides, which work by disrupting cell membranes.
Prototype RecA inhibitors potentiate the killing of a wide variety of pathogenic bacteria by a broad range of bactericidal antibiotics.
It was known for a while that some bactericidal antibiotics put bacterial respiration into over-drive, which, by producing too many oxygen radicals, becomes toxic to the pathogens.
Synereca screened over 115,000 compounds and discovered protype RecA inhibitors and compounds that potentiate the killing of a wide variety of pathogenic bacteria by a broad range of bactericidal antibiotics.