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The initial focus of Symberix is the development of two novel drugs that selectively inhibit a bacterial enzyme responsible for clinically serious side effects of certain pain and cancer medications.
The gastrointestinal microbiota composition is influenced by bile salts and in turn, bile salts themselves are chemically modified in the gut by bacterial enzymes such as bacterial bile salt hydrolase (BSH).
Other substituents attached to the ring (including selenium) can increase this strain further, which in turn increases the likelihood of bacterial enzymes opening it.
Unlike bleach and soap that destroy and dislodge germs, triclosan works by interfering with a specific bacterial enzyme, which not all bacteria have.
In the 1970s, the bacterial enzyme amylase replaced acid conversion in processing corn starch to glucose.
Anacor Pharmaceuticals (NASDAQ:ANAC) announced today that it has amended and expanded its research and development collaboration with GlaxoSmithKline (GSK) to provide GSK the option to extend its rights around the bacterial enzyme target leucyl-tRNA synthetase (LeuRS), as well as to add new programs for tuberculosis (TB) and malaria using Anacor's boron chemistry platform.
As a UT Dallas student, Rupert said, Sancar successfully purified and described a bacterial enzyme called photolyase, which is critical to this type of DNA repair.
A team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have determined how the bacterial enzyme known as Cas9, guided by RNA, is able to identify and degrade foreign DNA during viral infections, as well as induce site-specific genetic changes in animal and plant cells.
To make corn syrup commercially, instead of using an acid, a mixture of corn starch and water is treated first with alpha amylase, a bacterial enzyme that breaks the starch down into oligosaccharides, followed by the addition of gammaamylase, an enzyme isolated from the Aspergillus fungus that converts some of the oligosaccharides to glucose.
Washington, Jan 23 ( ANI ): Scientists have shed light on the crystal structure of quinol dependent nitric oxide reductase (qNOR), a bacterial enzyme that offers clues on the origins of our earliest oxygen-breathing ancestors.
It produces blue colonies on MI Blue under ambient light doe to the breakdown of IBDG by the bacterial enzyme [beta]-Glucurondase.
Sulfamethoxazole inhibits dihydropteroate synthase, the bacterial enzyme that catalyzes the incorporation of p-aminobenzoid acid into dihydropteroic acid, the immediate precursor of folic acid, while trimethoprim was specifically synthesized as an inhibitor of dihydrofolate-reductase (40).
The bacterial enzyme unwittingly acts as a device that hides the enemy, he says--perhaps even encouraging the bacteria to take in more of the toxic drug than they ordinarily would.
They hit on a way to attach an extra molecule to penicillin which is easily sliced off by the bacterial enzyme.
GSK '052 specifically targets the bacterial enzyme leucyl-transfer RNA synthetase, or LeuRS, which is required for protein synthesis.