In this case, the additional identification of bacterial DNA
suggests septicemia, with pathogenic bacteria presumably originating from the gastrointestinal tract.
Deciphering bacterial DNA
is simpler than deciphering human DNA since its genes run continuously, without gaps," Borodovsky explained.
coli), genetic materials, human and bacterial DNA
, and dozens of other pathogenic biological agents.
The experiment also involves cutting, splicing and cloning bacterial DNA
The company's approach, which employs a single reagent set to generate genomic bar codes based on bacterial DNA
, can cost-effectively identify thousands of strains in a single test from complex samples in three hours.
To achieve that, they designed a "genomic tape recorder" that lets researchers write new information into any bacterial DNA
Synereca's second program focuses on the inhibition of RecA, a key enzyme in bacterial DNA
repair and the development and transmission of antibiotic resistance.
For other simpler proteins, scientists have been able to insert relevant genes into bacterial DNA
, essentially turning the microorganisms into protein factories.
In its samples, the team found DNA from a total of 33 phyla from all three domains of life, although bacterial DNA
was the most abundant.
After excluding all known contaminants, bacterial DNA
was found that does not match any known species in world databases," said Sergei Bulat of the St Petersburg Nuclear Physics Institute.
It is a unique bacteriocin, coded in the bacterial DNA
as a unit containing three identical copies of the same bacteriocin gene.
These DNA patterns, called "fingerprints," are detected by separating bacterial DNA
into tiny pieces, placing the pieces in a gel, and then sending electricity through the gel.
It works by binding to bacterial DNA
and deactivating it -– switching off all primary functions in the bacterial cell and stopping it from reproducing.
studied samples of the bacterial DNA
extracted from blood samples of African patients with severe symptoms of infection to produce a high-quality reference genome sequence to find the genetic differences between ST313 and strains associated with milder disease.
In the present study, we evaluated a 16S rDNA based PCR to amplify and detect bacterial DNA
in the CSF and its applicability in routine diagnostic laboratories.