BNO-1055 attenuated the uptake and cytotoxicity of purine and pyrimidine-based nucleoside analogs (fludarabine, azidothymidine
, gemcitabine) but had no effect on the uptake of 5-FU or the non-nucleoside drug docetaxel.
Originally developed in the 1960s as a cancer treatment, the chemical compound azidothymidine
, or AZT, had languished in obscurity until Burroughs Wellcome, a major drug company, opened its considerable drug inventory for testing.
(AZT) on HIV-positive people (who had not yet
Body distribution of azidothymidine
bound to hexyl-cyanoacrylate nanoparticles after i.
Palliative local radiation therapy to the body cavity has been suggested (3), and other drugs have been used for PEL, including high-dose methotrexate (14), parenteral azidothymidine
and interferon-alpha (6, 15), and bortezomib (16).
The first generation antiretroviral (ARV) drug azidothymidine
(AZT) was introduced in 1987, with some moderate success in delaying disease progression by slowing replication of HIV in body cells.
Mitsuya's research led to the discovery of azidothymidine
(AZT), dideoxyinosine (ddI) and dideoxycytidine (ddC), drugs with formidable potency against HIV.
(AZT) was "re-discovered" as an anti-viral medicine in 1987 after initially being introduced to the market in 1964 as an (ultimately ineffective) anti-cancer drug.
A year earlier the agency had cut short the customary three-phase clinical-testing regimen and approved azidothymidine
, or AZT, after the drug showed strong results in its Phase II trials.
Later, the narrator records that "[a]gainst my will I became familiar with words like azidothymidine
, alpha interferon, domipramine, nitrazepam.
ALCAP, HA and TCP ceramic capsules has been studied for the delivery of steroids, drugs like azidothymidine
, epinephrine, anticancer drugs and antibiotics.
30) These regulations built on the process used for the first AIDS drug, azidothymidine
(zidovudine), and were applicable to drugs/biologics for life-threatening or severely debilitating diseases.
Also known as zidovudine and Retrovir, Azidothymidine
was approved by the FDA in March of 1987, just a few years after the disease had reached crisis level here in the U.
Understanding these mutations is critical because some can cause resistance to antibiotics such as azidothymidine
The experimental choice of template radically influences both the measured kinetic performance of the enzyme and its response to specific inhibitors, such as azidothymidine