treatment of hepatocellular carcinoma in rats: an in vivo study of telomerase inhibition.
Originally developed in the 1960s as a cancer treatment, the chemical compound azidothymidine
, or AZT, had languished in obscurity until Burroughs Wellcome, a major drug company, opened its considerable drug inventory for testing.
(AZT) on HIV-positive people (who had not yet
Body distribution of azidothymidine
bound to hexyl-cyanoacrylate nanoparticles after i.
The first generation antiretroviral (ARV) drug azidothymidine
(AZT) was introduced in 1987, with some moderate success in delaying disease progression by slowing replication of HIV in body cells.
Mitsuya's research led to the discovery of azidothymidine
(AZT), dideoxyinosine (ddI) and dideoxycytidine (ddC), drugs with formidable potency against HIV.
or zidovudine) to new populations (2).
A year earlier the agency had cut short the customary three-phase clinical-testing regimen and approved azidothymidine
, or AZT, after the drug showed strong results in its Phase II trials.
ALCAP, HA and TCP ceramic capsules has been studied for the delivery of steroids, drugs like azidothymidine
, epinephrine, anticancer drugs and antibiotics.
30) These regulations built on the process used for the first AIDS drug, azidothymidine
(zidovudine), and were applicable to drugs/biologics for life-threatening or severely debilitating diseases.
Also known as zidovudine and Retrovir, Azidothymidine
was approved by the FDA in March of 1987, just a few years after the disease had reached crisis level here in the U.
The question of whether Western standards should be applied in Africa and Asia first arose, Rothman says, after clinical trials in the United States determined in 1994 that the drug azidothymidine
(AZT), though highly toxic, significantly reduced the transmission of HIV from infected pregnant mothers to their children.
Understanding these mutations is critical because some can cause resistance to antibiotics such as azidothymidine
The experimental choice of template radically influences both the measured kinetic performance of the enzyme and its response to specific inhibitors, such as azidothymidine
Interim results from the study, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), demonstrate that a single oral dose of the antiretroviral drug nevirapine (NVP) given to an HIV-infected female in labor and another to her baby within 3 days of birth reduces the transmission rate by one-half compared with a similar short course of Azidothymidine