Inhibition of the enzyme increases the amount of noradrenaline, serotonin and dopamine in axon terminals.
When an action potential travels along a nerve and arrives at the axon terminal, it triggers the secretion of a neurotransmitter that allows the passage of a signal from one neuron to its neighbour via the synaptic cleft.
B] receptors are found on the axon terminals of both GABAergic and glutamatergic neurons, and thus the net effect of receptor activation can be either disinhibitory or inhibitory depending on which receptors are activated.
Members of these latter two mGluR subgroups reside predominantly on presynaptic axon terminals, where they act to inhibit neurotransmitter release (Coutinho and Knopfel 2002).
Neurons communicate with each other by chemicals called neurotransmitters that are transported from the cell body to the axon terminals where they are released.
Under normal circumstances, dopegal is formed in the axon terminals away from the cell's genetic instructions that contain a program for cell suicide, so it can not trigger the suicide message.