Chen's team demonstrated that both the macrophages and the autoantigens
are necessary for the treatment to work.
The 1A-2 autoantigen
is a protein tyrosine phosphatase transmembrane, cell surface molecule that may be involved in neuroendocrine secretory processes.
discovery with a synthetic human peptidome.
defined by experimental serum and B-cell analysis in RA syndromes in animals and humans (10) Type/nature Specificity Autoantigen
Citrulline-containing peptide Keratin Perinuclear factor Savoy antigen Filaggrin Human leukocyte antigen Calpastatin Immunoglobulin (rheumatoid factor) Calreticulin Antineutrophil cytoplasmic antigen Antinuclear antibody Immunoglobulin heavy-chain protein / p68 Heteronuclear ribonucleoprotein A2 (RA33) Glucose-6-phosphate isomerase Cartilage (organ Collagen type II specific) Chondrocyte antigen 65 Large aggregating chondroitin sulfate proteoglycan (aggrecan) Human chondrocyte glycoprotein 39 Cartilage oligomeric matrix protein Non-autoantigens
Bacterial heat shock protein
10-13) In 1997, identification of tissue transglutaminase type II as the major autoantigen
of CD (and also the epitope recognized by anti-endomysial antibodies) shed new light into the pathogenesis of this disease.
Desmoglein 3 protein has been identified as the autoantigen
of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.
Improved in planta expression of the human islet autoantigen
glutamic acid decarboxylase (GAD65).
Laminin gamma-1 is a major autoantigen
in anti-p-200 pemphigoid.
EBV-induced expression and HLA-DR-restricted presentation by human B cells of alpha B-crystallin, a candidate autoantigen
in multiple sclerosis.
These are patients with IgE antibodies directed to thyroid peroxidase as an autoantigen
Anti-[beta] cell autoimmunity also plays a role in the pathogenesis of STZ-induced diabetes: the presentation of [beta] cell autoantigen
by macrophages to helper-T cells, followed by the development of [beta] cell-specific cytotoxic cells (Ihm et al.
Caspase cleavage of the nuclear autoantigen
LEDGF/p75 abrogates its pro-survival function, implications for autoimmunity in atopic disorders.
A seminal vesicle autoantigen
of mouse is able to suppress capacitation-related events stimulated by serum albumin.
The human protein has been identified as an autoantigen
, with ~20% of patients with systemic lupus erythematosus and with antiSm autoantibodies synthesizing autoantibodies called antirRNP, to components of the ribosome (Hasegawa et al.
Increased prevalence of transfusion transmitted virus and cross reactivity with immunodominant epitopes of the HRES-1/ p28 endogenous retroviral autoantigen
in patients with systemic lupus erythematosus.