inhibitor

(redirected from aromatase inhibitor)
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  • noun

Antonyms for inhibitor

a substance that retards or stops an activity

References in periodicals archive ?
Entinostat's epigenetic mechanism may reverse resistance to hormonal therapy, delaying the need for toxic chemotherapeutic agents and improving survival when given in combination with aromatase inhibitors.
But I never addressed the joint and muscle pain that often accompanies the use of aromatase inhibitors.
Bone mineral density decreased over time in the exemestane group; however, patients on the aromatase inhibitor had no increased risk of fractures.
Aromatase inhibitors block the enzyme aromatase, which is responsible for conversion of the adrenal derived precursor, androstenedione, to estrogen in tissues such as fat, muscle, and in the breast in postmenopausal women.
Effect of an aromatase inhibitor on BMD and bone turnover markers: 2-year results of the Anastrozole, Tamoxifen, Alone or in Combination (ATAC) trial (18233230).
This is the first head-to-head study of these two aromatase inhibitors in the post-surgery setting and is expected to enrol 4,000 women worldwide.
Liz Caroll, from charity Breast Cancer Care, said: "These results further suggest the benefits of using aromatase inhibitors over tamoxifen in treating early invasive breast cancer and indicate that many more lives could be saved.
Coordinated by the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG), the ExCel research study will examine the potential benefit of the aromatase inhibitor exemestane.
In a recent trial comparing the aromatase inhibitor anastrozole (Arimidex) with tamoxifen, anastrozole significantly decreased spinal and hip bone mass after a median follow-up of 33 months, compared with tamoxifen.
Exemestane is a type of drug called an aromatase inhibitor which stops natural production of oestrogen, the hormone responsible for the growth and recurrence of many breast cancers.
Methods: Ten male patients with a diagnosis of IHH/PE were treated with the aromatase inhibitor anastrazole (1 mg/d orally).
Under the agreement, the Geneva-based company will have the rights to develop, register and market the aromatase inhibitor, Anastrozole.
The study showed that entinostat extended both progression-free survival and overall survival when added to exemestane in postmenopausal women with estrogen receptor-positive (ER+) breast cancer whose cancer had progressed after treatment with a nonsteroidal aromatase inhibitor.
Indeed, ongoing clinical trials are comparing outcomes with 10 versus the standard 5 years of adjuvant aromatase inhibitor therapy.
The approved indications are for increasing bone mass in women at high risk for fracture on adjuvant aromatase inhibitor therapy for breast cancer and in men at high risk for fracture on androgen deprivation therapy (ADT) for non-metastatic prostate cancer, the company's statement said.