For example, therapeutic agents with low aqueous solubility
, or ones in which bioactive forms exist in equilibrium with inactive forms, or agents that must be "dribbled in" because they are toxic in high doses.
The membrane is suitable for applications including natural product screening, aqueous solubility
testing and total drug analysis.
The partitioning of each of the individual chemicals between the water and the sediment compartments is governed by many factors, including aqueous solubility
, sediment binding, pH, and temperature.
Low-polarity organic contaminants, such as polychlorinated biphenyls (PCBs) and polyaromatic hydrocarbons (PAHs), are very persistent in the environment due to their low aqueous solubility
and poor bioavailability.
2), their aqueous solubility
was lower than that of isobutyryl thiocholine as shown in Table 2.
Demand is high for this technology, since more than 40% of drugs in development are estimated to have low aqueous solubility
Underpinned by pharmaceutical-industry estimates that approximately 40% of lipophilic therapeutic molecules are rejected because of their poor aqueous solubility
and formulation-stability issues, one of the main challenges facing modern pharmaceutical science is the development of carrier vehicles for the extended delivery of such drug candidates.
Comparison of Chromatographic and Spectroscopic Methods Used to Rank Compounds for Aqueous Solubility
The SDD technology has been successfully applied to more than 200 Pfizer compounds with low aqueous solubility
The aqueous solubility
of L-ascorbic acid at 7[degrees]C and 14[degrees]C are 16.
We added triazines to the cell culture medium at concentrations below their aqueous solubility