Rick Stewart, Chief Executive Officer of Amarin, commented on the new acquisition, "This oral formulation of apomorphine
potentially represents an important breakthrough for the treatment of Parkinson's disease patients experiencing "off" episodes.
These same people then received a placebo injection of a salt solution that they believed was apomorphine
Again, the apomorphine
was successful in controlling her symptoms but her stomach became hard and painful from the regular insertion of needles.
Nastech, a nasal drug company, recently started the second of three Food and Drug Administration-required phases of clinical trials for its apomorphine
hydrochloride product for women, which is designed to improve blood flow and lubricating secretions in female genitals.
In contrast, the erectogenic effects of apomorphine
HC1, administered as a sublingual tablet, are mediated at dopamine receptors in the hypothalamus and mid-brain.
Recent years have witnessed the introduction of new oral agents for the treatment of ED, including sildenafil and sublingual apomorphine
Oral Medications Peripheral agents * Sildenafil * L-arginine Adrenergic receptor antagonists * Yohimbine * Phentolamine (Vasomax[TM]) Dopamine receptor agonists * Apomorphine
Serotonergic receptor agonists * Trazodone Intraurethral Agents * Alprostadil (synthetic [PGE.
Treating centers chose the best medical therapy, including apomorphine
, for each patient as well as the specific surgical procedure (lesion or stimulation).
24 advanced patients implanted with deep-brain stimulators after they didn't respond or were sensitive to oral levodopa (the usual drug for the disease); 20 advanced patients given apomorphine
hydrochloride by injection or infusion pump while they waited an implant; and 30 healthy controls.
The trial has a number of strengths that improved on previous trials, including a larger number of patients, a longer follow-up, and treatment with continuous infusions of apomorphine
, a short-acting dopamine agonist, can be administered subcutaneously as a bolus or infusion, intranasally or sublingually.
The recent European approval of Archimedes' innovative fentanyl pectin nasal spray product for of breakthrough cancer pain (PecFent) is one example of a product specifically designed for purpose and there are numerous other nasal drugs in clinical development at Archimedes and elsewhere, including granisetron (nausea/vomiting), diazepam and midazolam (seizures), testosterone (hypogonadism) and apomorphine
Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine
A couple of washing soda crystals down the throat can work but injections of apomorphine
by the vet are more reliable.
Major finding: The proportional reporting ratio, similar to the relative risk ratio, was significant between pramipexole, ropinirole, cabergoline, bromocriptine, rotigotine, and apomorphine
on one hand, and a variety of impulse control disorders on the other.